Thymoquinone

The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer. Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa. It has anti-inflammatory effects, blocking the synthesis of leukotrienes. Thymoquinone inhibits the growth of leukemia cells (IC50 = 1.5 µg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression. In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 µM) suppresses STAT3-regulated gene expression and prevents angiogenesis.Formal Name: 2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione. CAS Number: 490-91-5. Synonyms: NSC 2228. Molecular Formula: C10H12O2. Formula Weight: 164.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 14 mg/ml, Ethanol: 16 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 253 nm. SMILES: O=C(C(C(C)C)=C1)C=C(C)C1=O. InChi Code: InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3. InChi Key: KEQHJBNSCLWCAE-UHFFFAOYSA-N.