Teniposide

Teniposide is a topoisomerase II poison. It promotes calf thymus topoisomerase II-mediated DNA cleavage when used at concentrations ranging from 0.04 to 40 µg/ml. Teniposide induces single- and double-stranded DNA breaks in a concentration-dependent manner. It inhibits the proliferation of A549 lung cancer cells (IC50 = 0.7 µM). Teniposide induces cell cycle arrest at the S phase and apoptosis in Tca8113 tongue squamous cell carcinoma cells when used at a concentration of 5 mg/L and induces cell cycle arrest at the G2/M phase when used at 0.15 mg/L. It reduces tumor growth and inhibits metastasis in a 3LL murine Lewis lung carcinoma model when administered at a dose of 6.5 mg/kg. Formulations containing teniposide have been used in combination therapy in the treatment of refractory childhood acute lymphoblastic leukemia.Formal Name: (5R,5aR,8aR,9S)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-beta-D-glucopyranosyl]oxy]-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one. CAS Number: 29767-20-2. Synonyms: NSC 122819, VM-26. Molecular Formula: C32H32O13S. Formula Weight: 656.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 284 nm. SMILES: [H][C@@]12O[C@H](C3=CC=CS3)OC[C@@]1([H])O[C@](O[C@@H]4C(C=C(OCO5)C5=C6)=C6[C@@H](C7=CC(OC)=C(O)C(OC)=C7)[C@]8([H])[C@]4([H])COC8=O)([H])[C@H](O)[C@H]2O. InChi Code: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+. InChi Key: NRUKOCRGYNPUPR-QBPJDGROSA-N.