Tebipenem Pivoxil

Tebipenem pivoxil is a prodrug form of the carbapenem antibiotic tebipenem. Tebipenem pivoxil is metabolized by carboxylesterase (CES) in intestinal epithelial cells to form tebipenem. Tebipenem pivoxil is active against methicillin-sensitive and -resistant S. aureus (MRSA, MIC90s = =0.125 and 16 µg/ml, respectively), as well as E. faecalis, E. coli, K. pneumoniae, E. aerogenes, H. influenzae, and P. aeruginosa (MIC90s = 32, 1, 0.5, =0.125, 0.25, and 64 µg/ml, respectively). It increases survival in mouse models of sepsis induced by S. aureus, E. coli, or P. aeruginosa when administered at doses of 50 and 100 mg/kg.Formal Name: (4R,5S,6S)-3-[[1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester. CAS Number: 161715-24-8. Synonyms: TBPM-PI. Molecular Formula: C22H31N3O6S2. Formula Weight: 497.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml. lambdamax: 216, 321 nm. SMILES: O=C1N2C(C(OCOC(C(C)(C)C)=O)=O)=C(SC3CN(C4=NCCS4)C3)[C@H](C)[C@]2([H])[C@@]1([H])[C@H](O)C. InChi Code: InChI=1S/C22H31N3O6S2/c1-11-15-14(12(2)26)18(27)25(15)16(19(28)30-10-31-20(29)22(3,4)5)17(11)33-13-8-24(9-13)21-23-6-7-32-21/h11-15,26H,6-10H2,1-5H3/t11-,12-,14-,15-/m1/s1. InChi Key: SNUDIPVBUUXCDG-QHSBEEBCSA-N.