Description: Tebipenem Pivoxil (Orapenem) , an orally activity carbapenem antibiotic, is utilized in treating otolaryngologic and respiratory infections. Target: Antibacterial, Antibiotic. Smiles: C(OCOC(C(C)(C)C)=O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])([C@@H](C)C1SC3CN(C3)C4=NCCS4)[H]. References: Kato K, et...

Tebipenem pivoxil is a prodrug form of the carbapenem antibiotic tebipenem. Tebipenem pivoxil is metabolized by carboxylesterase (CES) in intestinal epithelial cells to form tebipenem. Tebipenem pivoxil is active against methicillin-sensitive and -resistant S. aureus (MRSA, MIC90s = =0.125 and 16 µg/ml,...