TCN 201

TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit (pIC50s = 6.8 and <4.3 for human recombinant NR2A and NR2B, respectively). It has been shown to bind to a novel allosteric site located at the dimer interface between the GluN1 and GluN2 binding domains, thereby reducing glycine signal transduction and inhibiting NMDA receptor function.Formal Name: 4-[[[(3-chloro-4-fluorophenyl)sulfonyl]amino]methyl]-benzoic acid, 2-benzoylhydrazide. CAS Number: 852918-02-6. Molecular Formula: C21H17ClFN3O4S. Formula Weight: 461.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH7.2) (1:40): 0.02 mg/ml, DMSO: 20 mg/ml. lambdamax: 232 nm. SMILES: O=C(NNC(C1=CC=C(CNS(C2=CC(Cl)=C(F)C=C2)(=O)=O)C=C1)=O)C3=CC=CC=C3. InChi Code: InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28). InChi Key: FYIBXBFDXNPBSF-UHFFFAOYSA-N.