TAK-041

TAK-041 is an agonist of G protein-coupled receptor 139 (GPR139). It induces calcium mobilization in cells expressing human GPR139 (EC50 = 22 nM). In vivo, TAK-041 (0.3 and 3 mg/kg) increases social interaction in mice.Formal Name: 4-oxo-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]-1,2,3-benzotriazine-3(4H)-acetamide. CAS Number: 1929519-13-0. Synonyms: NBI 1065864. Molecular Formula: C18H15F3N4O3. Formula Weight: 392.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 1 mg/ml. SMILES: O=C1C2=CC=CC=C2N=NN1CC(N[C@H](C3=CC=C(C=C3)OC(F)(F)F)C)=O. InChi Code: InChI=1S/C18H15F3N4O3/c1-11(12-6-8-13(9-7-12)28-18(19,20)21)22-16(26)10-25-17(27)14-4-2-3-5-15(14)23-24-25/h2-9,11H,10H2,1H3,(H,22,26)/t11-/m0/s1. InChi Key: JZGLECLGVQRPPI-NSHDSACASA-N.