16 products were found matching "K08428"!

NCRW0005-F05 is an antagonist of G protein-coupled receptor 139 (GPR139, IC50 = 0. µM).. Solulibility: DMSO: Soluble: = 10 mg/ml: Ethanol: Sparingly soluble: 1-10 mg/ml.

TC-O 9311 is an agonist of the orphan G protein-coupled receptor GPR139 (EC50 = 39 nM in a calcium mobilization assay). It is selective for GPR139 over a panel of 90 additional targets. TC-O 9311 (1 µM) inhibits cell death induced by 1-methyl-4-phenylpyridinium (MPP+), but not 6-hydroxydopamine (6-OHDA, Cay-25330),...

JNJ-63533054 is a potent agonist of the orphan G protein-coupled receptor GPR139 (EC50 = 16 nM in HEK293 cells expressing human GPR139). It is selective for GPR139 over 50 known G protein-coupled receptors, ion channels, and transporters as determined by an external selectivity panel. Tritium-labeled JNJ-63533054...

This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript...

Protein function: Orphan receptor. Seems to act through a G(q/11)-mediated pathway. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 98% and to rat: 98%

TAK-041 is an agonist of G protein-coupled receptor 139 (GPR139). It induces calcium mobilization in cells expressing human GPR139 (EC50 = 22 nM). In vivo, TAK-041 (0.3 and 3 mg/kg) increases social interaction in mice.Formal Name:...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Description: JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM. Target: GPR. Smiles: C[C@H](NC(=O)CNC(=O)c1cccc(Cl)c1)c1ccccc1. References: Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20,6(9):1015-8.

Description: TAK-041 (NBI-1065846) is a potent and selective GPR139 agonist. Target: GPCR. Smiles: C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1. References: Reichard HA, et al. Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with...

Protein function: Orphan receptor. Seems to act through a G(q/11)-mediated pathway. [The UniProt Consortium]

Protein function: Orphan receptor. Seems to act through a G(q/11)-mediated pathway. [The UniProt Consortium]

Orphan receptor. Seems to act through a G(q/11)-mediated pathway. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:4000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid...