Supinoxin

Supinoxin is an inhibitor of Y593-phosphorylated DEAD-box helicase 5 (DDX5). It binds to Y593-phosphorylated DDX5 (Kd = ~19 nM), but does not interact with unphosphorylated DDX5, and selectively inhibits beta-catenin-dependent ATPase activity over RNA-dependent ATPase activity at 0.2 µM. Supinoxin induces apoptosis in MDA-MB-231 cells (IC50 = 12 nM) and inhibits cell growth in SK-MEL-28 cells (IC50 = 20 nM).Formal Name: 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-2-quinoxalinyl)-1-piperazinecarboxamide. CAS Number: 888478-45-3. Synonyms: RX-5902. Molecular Formula: C22H24FN5O4. Formula Weight: 441.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml. lambdamax: 216, 252 nm. SMILES: O=C(N1CCN(CC1)C2=CC(OC)=CC(OC)=C2)NC3=NC4=C(N=C3OC)C=CC(F)=C4. InChi Code: InChI=1S/C22H24FN5O4/c1-30-16-11-15(12-17(13-16)31-2)27-6-8-28(9-7-27)22(29)26-20-21(32-3)25-18-5-4-14(23)10-19(18)24-20/h4-5,10-13H,6-9H2,1-3H3,(H,24,26,29). InChi Key: KAKPGJJRYRYSTP-UHFFFAOYSA-N.