Description: Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent, inducing cell apoptosis and inhibiting the growth of TNBC cancer cell lines (IC50s: 10 nM - 20 nM). Target: Apoptosis, DNA/RNA Synthesis. Smiles:...

Supinoxin is an inhibitor of Y593-phosphorylated DEAD-box helicase 5 (DDX5). It binds to Y593-phosphorylated DDX5 (Kd = ~19 nM), but does not interact with unphosphorylated DDX5, and selectively inhibits beta-catenin-dependent ATPase activity over RNA-dependent ATPase activity at 0.2 µM. Supinoxin induces apoptosis...