Sulfonadyn-47

Sulfonadyn-47 is a dynamin inhibitor. It inhibits dynamin GTPase activity in a cell-free assay (IC50 = 3.5 µM). Sulfonadyn-47 inhibits clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 µM), as well depolarization-stimulated uptake of FM4-64, a marker of synaptic vesicle endocytosis (SVE), in isolated rat brain synaptosomes (IC50 = 12.3 µM). In vivo, sulfonadyn-47 (30 and 60 mg/kg) has anticonvulsant activity in the 6 Hz corneal kindling mouse model of seizures.Formal Name: (E)-N-(3-((3-(4-bromophenyl)allyl)amino)propyl)naphthalene-1-sulfonamide. Molecular Formula: C22H23BrN2O2S. Formula Weight: 459.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. lambdamax: 221, 261 nm. SMILES: BrC1=CC=C(/C=C/CNCCCNS(=O)(C2=C(C=CC=C3)C3=CC=C2)=O)C=C1. InChi Code: InChI=1S/C22H23BrN2O2S/c23-20-13-11-18(12-14-20)6-4-15-24-16-5-17-25-28(26,27)22-10-3-8-19-7-1-2-9-21(19)22/h1-4,6-14,24-25H,5,15-17H2/b6-4+. InChi Key: ZYCDTZNHEUVRAI-GQCTYLIASA-N.