Suberohydroxamic Acid

Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 µM) and HDAC3 (IC50 = 0.30 µM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.Formal Name: N1,N8-dihydroxy-octanediamide. CAS Number: 38937-66-5. Synonyms: SBHA, Suberic bis-Hydroxamic Acid. Molecular Formula: C8H16N2O4. Formula Weight: 204.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml, DMSO: 1.25 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml. SMILES: ONC(CCCCCCC(NO)=O)=O. InChi Code: InChI=1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12). InChi Key: IDQPVOFTURLJPT-UHFFFAOYSA-N.