STING Agonist 23

STING agonist 23 is an agonist of stimulator of interferon genes (STING). It increases the phosphorylation of TANK-binding kinase 1 (TBK1) in wild-type, but not STING-deficient, HT-1080 cells when used at a concentration of 20 µM. STING agonist 23 induces dimerization of STING in THP-1 cells and mouse bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner. It inhibits the replication of herpes simplex virus (HSV), rhesus rotavirus (RRV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro (EC50s = 6.15, 6.8, and 10.71 µM, respectively). In vivo, STING agonist 23 increases serum levels of IFN-beta and TNF-alpha in mice.Formal Name: N,N'-(pentane-1,5-diyl)bis(5-nitrofuran-2-carboxamide). Synonyms: Stimulator of Interferon Genes Agonist 23. Molecular Formula: C15H16N4O8. Formula Weight: 380.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 16 mg/ml, DMSO: 14 mg/ml. lambdamax: 215, 308 nm. SMILES: O=C(NCCCCCNC(C1=CC=C([N+]([O-])=O)O1)=O)C2=CC=C([N+]([O-])=O)O2. InChi Code: InChI=1S/C15H16N4O8/c20-14(10-4-6-12(26-10)18(22)23)16-8-2-1-3-9-17-15(21)11-5-7-13(27-11)19(24)25/h4-7H,1-3,8-9H2,(H,16,20)(H,17,21). InChi Key: FWFARJQDNUCDBL-UHFFFAOYSA-N.