STING Agonist 1a

STING agonist 1a is an agonist of stimulator of interferon genes (STING). It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50 = 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-beta, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 (Cay-25857).Formal Name: 4-chloro-1-(2-chloro-6-methoxy-3-quinolinyl)-[1,2,4]triazolo[4,3-a]quinoxaline. CAS Number: 652142-94-4. Synonyms: Stimulator of Interferon Genes Agonist 1a. Molecular Formula: C19H11Cl2N5O. Formula Weight: 396.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly soluble, DMSO: slightly soluble, PBS (pH 7.2): slightly soluble. lambdamax: 218, 250 nm. SMILES: ClC1=NC2=C(N3C1=NN=C3C4=C(Cl)N=C5C=CC(OC)=CC5=C4)C=CC=C2. InChi Code: InChI=1S/C19H11Cl2N5O/c1-27-11-6-7-13-10(8-11)9-12(16(20)22-13)18-24-25-19-17(21)23-14-4-2-3-5-15(14)26(18)19/h2-9H,1H3. InChi Key: ABGPUQXRCXUIFE-UHFFFAOYSA-N.