SR 4370

SR 4370 is an inhibitor of histone deacetylase 3 (HDAC3, IC50 = 6 nM). It is selective for HDAC3 over HDAC1, -2, -6, and -8 (IC50s = 0.13, 0.58, 3.7, and 2.3 µM, respectively). SR 4370 decreases viability of MDA-MB-231 human breast cancer cells with an IC50 value of 12.6 µM.Formal Name: 2',3'-difluoro-[1,1'-biphenyl]-4-carboxylic acid, 2-butylhydrazide. CAS Number: 1816294-67-3. Molecular Formula: C17H18F2N2O. Formula Weight: 304.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 261 nm. SMILES: FC1=CC=CC(C2=CC=C(C(NNCCCC)=O)C=C2)=C1F. InChi Code: InChI=1S/C17H18F2N2O/c1-2-3-11-20-21-17(22)13-9-7-12(8-10-13)14-5-4-6-15(18)16(14)19/h4-10,20H,2-3,11H2,1H3,(H,21,22). InChi Key: OSQKWTZHYXRTBG-UHFFFAOYSA-N.