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Peroxisome proliferator-activated receptor gamma (PPARgamma) is activated by the anti-diabetes drugs known as thiazolidinediones, including rosiglitazone (Cay-71740) and pioglitazone (Cay-71745). Phosphorylation of PPARgamma by cyclin-dependent kinase 5 (Cdk5) causes dysregulation of genes whose expression is altered in obesity, including adiponectin. SR 1824 is a non-agonist PPARgamma ligand (Ki = 10 nM) which blocks Cdk5-mediated phosphorylation. It does not inhibit activation of PPARgamma by rosiglitazone (Cay-71740).Formal Name: (S)-4'-((5-((1-(4-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid. CAS Number: 1338259-06-5. Molecular Formula: C33H29BrN2O3. Formula Weight: 581.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 252 nm. SMILES: BrC1=CC=C([C@H](C)NC(C2=CC=C(N(CC3=CC=C(C4=CC=CC=C4C(O)=O)C=C3)C(C)=C5C)C5=C2)=O)C=C1. InChi Code: InChI=1S/C33H29BrN2O3/c1-20-22(3)36(19-23-8-10-25(11-9-23)28-6-4-5-7-29(28)33(38)39)31-17-14-26(18-30(20)31)32(37)35-21(2)24-12-15-27(34)16-13-24/h4-18,21H,19H2,1-3H3,(H,35,37)(H,38,39)/t21-/m0/s1. InChi Key: HBMXDCXJXYASGW-NRFANRHFSA-N.
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