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SR 0987 is an agonist of the T cell-specific isoform of RORgamma (RORgammat, retinoic acid receptor-related orphan receptor-gammat), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA (Cay-10008014) and ionomycin (Cay-10004974), increases expression of the RORgammat target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.Formal Name: 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide. CAS Number: 303126-97-8. Molecular Formula: C16H10ClF6NO2. Formula Weight: 397.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 30 mg/ml. lambdamax: 255 nm. SMILES: ClC1=CC=CC=C1C(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O. InChi Code: InChI=1S/C16H10ClF6NO2/c17-12-4-2-1-3-11(12)13(25)24-10-7-5-9(6-8-10)14(26,15(18,19)20)16(21,22)23/h1-8,26H,(H,24,25). InChi Key: IZVBONMVWLTLNT-UHFFFAOYSA-N.
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