- Search results for K08534
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62 products were found matching "K08534"!
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Item number: IB-IB04001
This human RAR-related orphan receptor gamma (RORgamma) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORgamma. Variant 2 mRNA comprises an alternate exon 1 that...
Keywords: | RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, RAR-related orphan receptor C, Retinoid-related... |
Application: | Functional activity screening |
Species reactivity: | human |
From 1,448.00€
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Item number: NSJ-RQ7200
0.5mg/ml if reconstituted with 0.2ml sterile DI water. RAR-related orphan receptor gamma (RORg) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone...
Keywords: | Anti-RORC, Anti-NR1F3, Anti-Nuclear receptor ROR-gamma, Anti-Nuclear receptor RZR-gamma, Anti-RAR-related orphan receptor... |
Application: | WB, FC, Direct ELISA |
Host: | Rabbit |
Species reactivity: | human |
755.00€
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Item number: ELK-ELK4344.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RORg. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RORg. Next,...
Keywords: | RORC, NR1F3, Nuclear receptor RZR-gamma, Nuclear receptor ROR-gamma, RAR-related orphan receptor C, Retinoid-related... |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: Cay20974-25
GSK2981278 is an inverse agonist of retinoic acid receptor-related nuclear receptor gamma (RORgamma, IC50 = 17 nM in a transactivation assay). It is selective for RORgamma over RORalpha. GSK2981278 inhibits IL-17A and IL-22 protein secretion from isolated human peripheral blood T cells grown under Th17 skewing...
Keywords: | N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-benzenesulfonamide |
Application: | Potent, selective ROR gamma inverse agonist |
CAS | 1474110-21-8 |
MW: | 461.6 D |
From 50.00€
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Item number: Cay11972-1
Retinoic acid receptor-related nuclear receptor gamma (RORgamma) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis. SR 2211 selectively binds RORgamma (Ki =...
Keywords: | 2-fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-alpha,alpha-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol |
Application: | ROR gamma agonist |
CAS | 1359164-11-6 |
MW: | 527.5 D |
From 50.00€
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Item number: Cay10922-1
Retinoic-acid-receptor-related orphan receptors (ROR) alpha and gamma play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a...
Keywords: | N-(5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)sulfamoyl)-4-methylthiazol-2-yl)acetamide |
Application: | RORalpha and RORgamma inverse agonist |
CAS | 1335106-03-0 |
MW: | 477.4 D |
From 43.00€
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Item number: LKT-S6800.5
RORalpha/gamma inverse agonist.
Application: | RORalpha/gamma inverse agonist |
CAS | 1335106-03-0 |
MW: | 477.4 D |
From 82.00€
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Item number: Cay19503-1
SR 0987 is an agonist of the T cell-specific isoform of RORgamma (RORgammat, retinoic acid receptor-related orphan receptor-gammat), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA (Cay-10008014) and ionomycin...
Keywords: | 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide |
Application: | RORgammat agonist |
CAS | 303126-97-8 |
MW: | 397.7 D |
From 34.00€
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Item number: Cay26209-5
Zymostenol is a late-stage precursor in the biosynthesis of cholesterol. It is an agonist of retinoic acid receptor-related orphan receptor gamma (RORgamma) with an EC50 value of 1 µM in a RORgamma coactivator recruitment assay in the presence of ursolic acid (Cay-10072). It increases the number of myelin basic...
Keywords: | Delta8-Cholesterol, (5alpha)-cholest-8-en-3beta-ol |
Application: | Late-stage cholesterol biosynthesis precursor, RORgamma agonist |
CAS | 566-97-2 |
MW: | 386.7 D |
From 141.00€
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Item number: Cay11003-1
RORgamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis...
Keywords: | NR1F3, RAR-Related Orphan Receptor C, Retinoid-Related Orphan Receptor gamma |
Application: | IHC, WB |
Host: | Rabbit |
Species reactivity: | human |
369.00€
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Item number: Cay12071-1
Retinoic acid receptor-related nuclear receptor gamma (RORgamma) plays a central role in T cell differentiation, particularly in the development of TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis. SR 1555 is a selective ligand of RORgamma (IC50 = 1 µM). It...
Keywords: | 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone,... |
Application: | RORgamma ligand |
CAS | 2309312-90-9 |
MW: | 496.9 D |
From 43.00€
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Item number: IB-M04001
Protein function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and...
Keywords: | TOR, Rorc, Nr1f3, Thymus orphan receptor, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, RAR-related orphan... |
Application: | Functional activity screening |
Species reactivity: | mouse |
From 1,448.00€
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