82 products were found matching "K08534"!
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RORgamma (human) Reporter Assay Kit
Item number: IB-IB04001
This human RAR-related orphan receptor gamma (RORgamma) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORgamma. Variant 2 mRNA comprises an alternate exon 1 that...
| Keywords: | RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, RAR-related orphan receptor C, Retinoid-related... |
| Application: | Functional activity screening |
| Species reactivity: | human |
From 1,507.00€
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XY-018
Item number: Cay43111-10
XY-018 is an inverse agonist of retinoic acid receptor-related orphan receptor gamma (RORgamma). It induces RORgamma transcriptional activity in a reporter assay using LNCaP cells (IC50 = 0. µM). XY-018 selectively induces RORgamma transcriptional activity over RORalpha transcriptional activity in HEK293T cells...
| Keywords: | N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-2-nitro-benzeneacetamide |
| Application: | ROR gamma inverse agonist |
| CAS | 1873358-87-2 |
| MW: | 516.37 D |
From 151.00€
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Anti-RoRgT
Item number: ABS-KC-3300.100
Protein function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and...
| Keywords: | RoRgT Antibody |
| Application: | IHC |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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GSK2981278
Item number: Cay20974-25
GSK2981278 is an inverse agonist of retinoic acid receptor-related nuclear receptor gamma (RORgamma, IC50 = 17 nM in a transactivation assay). It is selective for RORgamma over RORalpha. GSK2981278 inhibits IL-17A and IL-22 protein secretion from isolated human peripheral blood T cells grown under Th17 skewing...
| Keywords: | N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-benzenesulfonamide |
| Application: | Potent, selective ROR gamma inverse agonist |
| CAS | 1474110-21-8 |
| MW: | 461.6 D |
From 52.00€
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SR0987
Item number: TGM-T4670-100mg
Description: SR0987 is a RORgammat agonist,. Target: ROR. Smiles: OC(c1ccc(NC(=O)c2ccccc2Cl)cc1)(C(F)(F)F)C(F)(F)F. References: Chang MR, et al. Synthetic RORgammat Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15,11(4):1012-8.
| Application: | RORgammat agonist |
| CAS | 303126-97-8 |
| MW: | 397.7 D |
From 63.00€
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GSK2981278
Item number: TGM-T4050-100mg
Description: GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). Target: ROR. Smiles: CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(CO)c1. References: Birault Veronique, et al. Preparation of...
| Keywords: | ROR gama modulator 1 |
| Application: | Potent, selective ROR gamma inverse agonist |
| CAS | 1474110-21-8 |
| MW: | 461.61 D |
From 37.00€
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SR1001
Item number: TGM-T5163-100mg
Description: SR 1001 is an inverse agonist for RORalpha/RORgamma (Kis: 172/111 nM). Target: ROR. Smiles: CC(=O)Nc1nc(C)c(s1)S(=O)(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F. References: Solt LA, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 2011 Apr 28,472(7344):491-4.
| Application: | RORalpha and RORgamma inverse agonist |
| CAS | 1335106-03-0 |
| MW: | 477.4 D |
From 34.00€
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RORgammat inhibitor 2
Item number: TGM-T72595-100mg
Description: RORgammat Inhibitor 2, a potent inhibitor of RORgammat, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are mediated by RORgammat. Target: Others. Smiles:...
| Application: | ROR-gamma-t inhibitor |
| CAS | 2673278-10-7 |
| MW: | 672.66 D |
From 2,272.00€
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Cedirogant
Item number: TGM-T9635-100mg
Description: Cedirogant (ABBV-157) is an orally active, retinoid-related orphan receptor-gammat (RORgammat) inverse agonist used in psoriasis studies. Target: ROR. Smiles: OC(=O)CC1CCN(CC1)C(=O)c1ccc(Cl)c(Cn2ccc3cc(cc(Cl)c23)C(F)(F)F)c1Cl. References: Elena Campione, et al. Experimental Pharmacological Management of...
| Keywords: | ABBV-157 |
| Application: | Targets RAR-related orphan receptor gamma (NR1F3, RORC) |
| CAS | 2055496-11-0 |
| MW: | 547.78 D |
From 88.00€
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RORC Protein, Human, Recombinant (His & SUMO)
Item number: TGM-TMPH-01792-100ug
Description: RORC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.2 kDa and the accession number is P51449.
| Keywords: | RAR-related orphan receptor C, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor ROR-gamma, RORC, Nuclear... |
| MW: | 74.2 kD |
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Cintirorgon
Item number: TGM-TQ0007-100mg
Description: Cintirorgon (LYC-55716) is a selective, oral agonist of RORgamma, modulating gene expression in RORgamma-expressing T lymphocyte immune cells. Target: ROR. Smiles: CC(C)(C[C@H]1CN(c2cc(ccc2O1)-c1cc(F)cc(OC(F)F)c1)S(=O)(=O)c1cccc(c1)C(F)(F)F)C(O)=O. References: Lycera Announces Initiation of Phase 1/2a...
| Keywords: | LYC-55716 |
| Application: | RORgamma agonist |
| CAS | 2055536-64-4 |
| MW: | 603.53 D |
From 77.00€
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SR2211
Item number: TGM-T16929-100mg
Description: SR2211 is a specific modulator and an inverse agonist of RORgamma(IC50 = 320 nM, Ki = 105 nM). Target: ROR. Smiles: OC(c1ccc(c(F)c1)-c1ccc(CN2CCN(Cc3ccncc3)CC2)cc1)(C(F)(F)F)C(F)(F)F. References: Kumar N, et al. Identification of SR2211: a potent synthetic RORgamma-selective modulator. ACS Chem Biol....
| Application: | ROR gamma agonist |
| CAS | 1359164-11-6 |
| MW: | 527.48 D |
From 45.00€
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