SER-601

SER-601 is a potent and selective peripheral cannabinoid (CB2) receptor agonist with 190-fold selectivity for CB2 over the central CB1 receptor (Kis = 6.3 and 1,220 nM, respectively). At 3 mg/kg, SER-601 has analgesic effects in a formalin-induced nocifensive study in mice without cannabis-like behavioral effects due to its low affinity for the CB1 receptor. SER-601 also has antidiabetic effects. Two to four week exposure to SER-601 ameliorates insulin resistance in vivo and increases insulin secretion and accumulation in pancreatic islets isolated from high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice.Formal Name: 1,4-dihydro-6-(1-methylethyl)-4-oxo-1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-3-quinolinecarboxamide. CAS Number: 1048038-90-9. Molecular Formula: C28H38N2O2. Formula Weight: 434.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, Ethanol: 3 mg/ml. lambdamax: 217, 250, 258, 307, 323, 335 nm. SMILES: CC(C)C1=CC2=C(N(CCCCC)C=C(C(NC3(C[C@H]4C5)C[C@@H](C4)C[C@@H]5C3)=O)C2=O)C=C1. InChi Code: InChI=1S/C28H38N2O2/c1-4-5-6-9-30-17-24(26(31)23-13-22(18(2)3)7-8-25(23)30)27(32)29-28-14-19-10-20(15-28)12-21(11-19)16-28/h7-8,13,17-21H,4-6,9-12,14-16H2,1-3H3,(H,29,32)/t19-,20+,21-,28?. InChi Key: KUMKLUDNETVLDS-XMURTRJZSA-N.