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SC144 is an orally bioavailable gp130 inhibitor. It inhibits phosphorylation of STAT1, STAT3, and Akt induced by leukemia inhibitory factor (LIF) and IL-6, but not IFN-gamma, in OVCAR-8 ovarian cancer cells when used at a concentration of 20 µM. SC144 induces cell cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines, including prostate, ovarian, lung, breast, and colorectal cancer cells, with IC50 values ranging from 0.4 to 4 µM. It reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models.Formal Name: 2-pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide, monohydrochloride. CAS Number: 917497-70-2. Molecular Formula: C16H11FN6O . HCl. Formula Weight: 358.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 5 mg/ml. lambdamax: 269, 314 nm. SMILES: FC1=CC=C2C(N=C(NNC(C3=NC=CN=C3)=O)C4=CC=CN42)=C1.Cl. InChi Code: InChI=1S/C16H11FN6O.ClH/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12,/h1-9H,(H,20,21)(H,22,24),1H. InChi Key: LKFGGXYXFIICED-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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