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SC-13 is an inhibitor of flap endonuclease 1 (FEN1, IC50 = 4.2 nM) and an activator of stimulator of interferon genes (STING). It increases the levels of gamma histone H2AX (gammaH2AX) in MCF-7 and MDA-MB-231 breast cancer cells when used at a concentration of 40 µM. SC13 (20 or 50 µM) induces chromosomal aberrations in MCF-7 cells. It potentiates the proliferation inhibition induced by cisplatin (Cay-13119), 5-fluorouracil (Cay-14416), or temozolomide (Cay-14163) in MCF-7 cells when used at a concentration of 20 µM. SC-13 (20 µM) increases levels of cyclic GMP-AMP (cGAMP) synthase (cGAS), phosphorylated STING, chemokine (C-C motif) ligand 5 (CCL5), and CCL10 in HeLa cervical cancer and MCF-7 cells. In vivo, SC-13 (5 mg/kg every other day), in combination with T cells expressing chimeric antigen receptors (CARs), reduces tumor volume and weight without affecting body weight, as well as increases the number of CD8+ T cell tumor infiltrates, in a HeLa mouse xenograft model.Formal Name: N-[3-[(3,4-dihydro-2,4-dioxo-3-propylthieno[3,2-d]pyrimidin-1(2H)-yl)methyl]phenyl]-benzeneacetamide. CAS Number: 2098776-03-3. Synonyms: FEN1 inhibitor SC-13, FEN1-IN-SC-13, Flap Endonuclease 1 Inhibitor SC-13, Flap Endonuclease 1-IN-SC-13. Molecular Formula: C24H23N3O3S. Formula Weight: 433.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: O=C(NC1=CC=CC(CN(C2=C3SC=C2)C(N(CCC)C3=O)=O)=C1)CC4=CC=CC=C4. InChi Code: InChI=1S/C24H23N3O3S/c1-2-12-26-23(29)22-20(11-13-31-22)27(24(26)30)16-18-9-6-10-19(14-18)25-21(28)15-17-7-4-3-5-8-17/h3-11,13-14H,2,12,15-16H2,1H3,(H,25,28). InChi Key: USTMMKOHIRMBIV-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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