- Search results for K04799
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29 products were found matching "K04799"!
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Item number: Cay39717-1
SC-13 is an inhibitor of flap endonuclease 1 (FEN1, IC50 = 4.2 nM) and an activator of stimulator of interferon genes (STING). It increases the levels of gamma histone H2AX (gammaH2AX) in MCF-7 and MDA-MB-231 breast cancer cells when used at a concentration of 40 µM. SC13 (20 or 50 µM) induces chromosomal...
Keywords: | FEN1 inhibitor SC-13, FEN1-IN-SC-13, Flap Endonuclease 1 Inhibitor SC-13, Flap Endonuclease 1-IN-SC-13,... |
Application: | FEN1 inhibitor, STING activator |
CAS | 2098776-03-3 |
MW: | 433.5 D |
From 34.00€
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Item number: Cay37790-1
FEN1-IN-4 is an inhibitor of flap endonuclease 1 (FEN1, IC50 = 30 nM for FEN1-336Delta). It also inhibits exonuclease 1 in a concentration-dependent manner. FEN1-IN-4 (10 µM) inhibits ATP-induced mitochondrial DNA (mtDNA) fragmentation and levels of cytosolic mtDNA in LPS-primed primary mouse bone marrow-derived...
Keywords: | FEN1 Inhibitor 4, Flap Endonuclease 1 Inhibitor 4, 1-(cyclopropylmethyl)-3-hydroxy-2,4(1H,3H)-quinazolinedione |
Application: | FEN1 inhibitor |
CAS | 1995893-58-7 |
MW: | 232.2 D |
From 48.00€
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Item number: ARG54167.100
Protein function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream...
Keywords: | Anti-MF1, Anti-RAD2, Anti-FEN-1, Anti-hFEN-1, Anti-DNase IV, Anti-Flap endonuclease 1, Anti-Maturation factor 1, Anti-Flap... |
Application: | WB, ICC, IF |
Host: | Mouse |
Species reactivity: | human, mouse, rat, monkey, hamster |
624.00€
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Item number: ARG54168.100
Protein function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream...
Keywords: | Anti-MF1, Anti-RAD2, Anti-FEN-1, Anti-hFEN-1, Anti-DNase IV, Anti-Flap endonuclease 1, Anti-Maturation factor 1, Anti-Flap... |
Application: | WB, IP |
Host: | Mouse |
Species reactivity: | human, mouse, rat |
624.00€
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Item number: A300-255A
Protein function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream...
Keywords: | Anti-MF1, Anti-RAD2, Anti-FEN-1, Anti-hFEN-1, Anti-DNase IV, Anti-Maturation factor 1, Anti-Flap endonuclease 1, Anti-Flap... |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human, mouse |
From 164.00€
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Item number: A300-256A
Protein function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream...
Keywords: | Anti-MF1, Anti-RAD2, Anti-FEN-1, Anti-hFEN-1, Anti-DNase IV, Anti-Maturation factor 1, Anti-Flap endonuclease 1, Anti-Flap... |
Application: | WB, IP, IHC |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: Cay14199-100
Flap endonuclease 1 (FEN1), a RAD2 Class II nuclease, plays a crucial role in DNA repair, replication, and genomic stability. FEN1 removes the 5'-unannealed flap during Okazaki fragment processing in lagging strand DNA synthesis. Removal of the DNA flap is also critical in long-patch base excision repair and...
Keywords: | FLAP Endonuclease 1, hFEN-1 |
Application: | Enzyme activity, WB |
Expressed in: | E.coli |
Origin: | human |
MW: | 43.8 kD |
530.00€
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Item number: IHC-00335
Protein function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream...
Keywords: | Anti-MF1, Anti-RAD2, Anti-FEN-1, Anti-hFEN-1, Anti-DNase IV, Anti-Maturation factor 1, Anti-Flap endonuclease 1, Anti-Flap... |
Application: | IHC |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: ARG57833.100
Protein function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream...
Keywords: | Anti-MF1, Anti-RAD2, Anti-FEN-1, Anti-hFEN-1, Anti-DNase IV, Anti-Maturation factor 1, Anti-Flap endonuclease 1, Anti-Flap... |
Application: | ICC, IF, IP |
Host: | Rabbit |
Species reactivity: | human |
624.00€
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Item number: E-AB-60232.120
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto...
Keywords: | Anti-MF1, Anti-RAD2, Anti-FEN-1, Anti-hFEN-1, Anti-DNase IV, Anti-Flap endonuclease 1, Anti-Maturation factor 1, Anti-Flap... |
Application: | IHC, IF, IP |
Host: | Rabbit |
Species reactivity: | human, mouse |
From 198.00€
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Item number: NSJ-RQ5695
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene. It is mapped to 11q12.2. The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis....
Keywords: | Anti-MF1, Anti-RAD2, Anti-FEN-1, Anti-hFEN-1, Anti-DNase IV, Anti-Flap endonuclease 1, Anti-Maturation factor 1, Anti-Flap... |
Application: | WB, IHC (paraffin), IF, FC, Direct ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
755.00€
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Item number: G-CAB1175.100
Application: | IF, IHC, IP, WB |
Host: | Rabbit |
Species reactivity: | human, mouse |
From 352.00€
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