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SB939 is a pan-inhibitor of histone deacetylases (HDACs, Kis = 16-247 nM for HDAC1-11). It inhibits proliferation of A2780, COLO 205, HCT116, and PC3 cancer cells (IC50s = 0.48, 0.56, 0.48, and 0.34 µM, respectively). SB939 (50 and 100 mg/kg) reduces tumor growth and increases survival in an HCT116 mouse xenograft model. It synergizes with pacritinib (Cay-16709) to decrease the number of metastases in a MOLM-13 mouse xenograft model when administered at a dose of 75 mg/kg.Formal Name: 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2E-propenamide. CAS Number: 929016-96-6. Synonyms: Pracinostat. Molecular Formula: C20H30N4O2. Formula Weight: 358.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 249, 303 nm. SMILES: CCN(CC)CCN1C2=C(N=C1CCCC)C=C(/C=C/C(NO)=O)C=C2. InChi Code: InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+. InChi Key: JHDKZFFAIZKUCU-ZRDIBKRKSA-N.
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