[Sar9, Met(O2)11]-Substance P (trifluoroacetate salt)

[Sar9, Met(O2)11]-Substance P (Sar-SP) is a peptide agonist of the neurokinin-1 (NK1) receptor. It is selective for NK1 over NK2 and NK3 receptors. Sar-SP induces inositol phosphate formation in U373MG glioblastoma cells with an EC50 value of 3.8 nM, an effect that can be blocked by the NK1 receptor antagonist SR 140333. It induces contractions in isolated human bronchi when used at concentrations of 3, 100, and 1,000 nM. Sar-SP (10, 25, 65, and 100 pmol/animal, i.c.v.) increases mean arterial pressure and heart rate in conscious rats.Formal Name: (S)-2-((S)-1-(L-arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylsulfonyl)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)(methyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide. Synonyms: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{Sar}-Leu-Met[O2]-NH2. Molecular Formula: C64H100N18O15S . XCF3COOH. Formula Weight: 1393.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N(C)CC(N[C@@H](CC(C)C)C(N[C@@H](CCS(C)(=O)=O)C(N)=O)=O)=O)=O)=O)=O)=O)[C@H]3N(C([C@@H](NC([C@H]4N(C([C@@H](N)CCCNC(N)=N)=O)CCC4)=O)CCCCN)=O)CCC3.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C64H100N18O15S.C2HF3O2/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71,3-2(4,5)1(6)7/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72),(H,6,7)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,/m0./s1. InChi Key: VDZDOTCGVUBCPG-LYQMAKBCSA-N.