Salermide

The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis. Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~20 µM) by reactivating proapototic genes that are repressed by SIRT1.Formal Name: N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide. CAS Number: 1105698-15-4. Molecular Formula: C26H22N2O2. Formula Weight: 394.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.25 mg/ml. lambdamax: 207, 233, 318, 365, 440, 459 nm. SMILES: OC1=CC=C2C=CC=CC2=C1/C=N/C3=CC(NC(C(C)C4=CC=CC=C4)=O)=CC=C3. InChi Code: InChI=1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+. InChi Key: HQSSEGBEYORUBY-WPWMEQJKSA-N.