SAG

SAG
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11914-1 1 mg -

6 - 10 business days*

34.00€
Cay11914-5 5 mg -

6 - 10 business days*

118.00€
Cay11914-10 10 mg -

6 - 10 business days*

152.00€
Cay11914-50 50 mg -

6 - 10 business days*

502.00€
 
Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO... more
Product information "SAG"
Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 µM). It directly binds to SMO and can block SMO inhibition by cyclopamine. Binding of SAG alters the conformation of SMO, leading to its accumulation in cilia and activation of gene transcription. At 15-240 nM, SAG prevents the neurotoxic effects of glucocorticoids without interfering with the beneficial effects of glucocorticoids on lung maturation. At higher concentrations (0.4 mM), SAG improves the conversion of human induced pluripotent stem cells to the neural lineage.Formal Name: 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide. CAS Number: 912545-86-9. Synonyms: Smoothened Agonist. Molecular Formula: C28H28ClN3OS. Formula Weight: 490.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 230 nm. SMILES: O=C(C(SC1=CC=CC=C21)=C2Cl)N([C@@H]3CC[C@@H](NC)CC3)CC4=CC(C5=CC=NC=C5)=CC=C4. InChi Code: InChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-. InChi Key: VFSUUTYAEQOIMW-YHBQERECSA-N.
Keywords: Smoothened Agonist, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide
Supplier: Cayman Chemical
Supplier-Nr: 11914

Properties

Application: Smo Agonist
MW: 490.1 D
Formula: C28H28ClN3OS
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 912545-86-9| Matching products
KEGG ID : K06226 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H413
P Phrases: P264, P270, P273, P321, P330, P301+P310, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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