- Search results for K06226
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55 products were found matching "K06226"!
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Item number: Cay11914-1
Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 µM). It directly binds to SMO and can block SMO inhibition by cyclopamine. Binding of SAG alters the conformation of SMO, leading to its...
Keywords: | Smoothened Agonist,... |
Application: | Smo Agonist |
CAS | 912545-86-9 |
MW: | 490.1 D |
From 34.00€
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Item number: AG-CR1-3585-M005
Soluble in water or DMSO. Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations....
Keywords: | N-Methyl-N?-(3-pyridinylbenzyl)-N?-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane . 2HCl |
Application: | SMO agonist |
CAS | 364590-63-6 |
MW: | 581 D |
From 55.00€
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Item number: BPS-27010
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Application: | Hedgehog signaling inhibitor |
CAS | 879085-55-9 |
MW: | 421.3 D |
191.00€
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Item number: BPS-27013
Cyclopamine inhibits activation of the Hedgehog response pathway by binding to and inhibiting the proto-oncogene Smoothened (SMO). The effects of oncogenic mutations that either activate SMO or inactivate the tumor suppressor Patched (Ptch) can be reversed by cyclopamine treatment. Cyclopamine has also been shown to...
Application: | SMO inhibitor |
MW: | 411.6 D |
276.00€
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Item number: AG-CR1-3506-M001
Cell permeable smoothened (Smo) agonist - Shown to induce Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo - Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations.
Keywords: | N-Methyl-N'-(3-pyridinylbenzyl)-N'-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane |
Application: | Smo Agonist |
CAS | 912545-86-9 |
MW: | 490,1 D |
From 55.00€
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Item number: Cay9001369-1
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 µM), and this activation is selective for the...
Keywords: | Click Tag(TM) Nat-20(S)-yne, 26,27-dinorcholest-5-en-24-yne-3beta,20-diol |
Application: | Allosteric SMO activator |
CAS | 1397692-46-4 |
MW: | 370.6 D |
From 82.00€
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Item number: Cay16240-5
Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell...
Keywords: | XL 139, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-benzamide |
Application: | Smo inhibitor |
CAS | 1059734-66-5 |
MW: | 473.6 D |
From 84.00€
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Item number: AG-CR1-3523-M001
Soluble in DMSO. Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524).
Keywords: | 22-Azacholesterol, (3beta)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol |
Application: | Hedgehog signaling inhibitor |
CAS | 360068-87-7 |
MW: | 424,1 D |
From 66.00€
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Item number: Cay16263-1
LDE225 is a smoothened (Smo) antagonist (IC50s = 1.3 and 2.5 nM for mouse and human Smo, respectively). In vivo, LDE225 (20 mg/kg per day) inhibits Gli1 mRNA expression and prevents tumor growth in an orthotopic Ptch+/- p53-/- medulloblastoma mouse allograft model. Formulations containing LDE225 have been used in...
Keywords: | Erismodegib, NVP-LDE225, Sonidegib,... |
Application: | Smo antagonist |
CAS | 1218778-77-8 |
MW: | 681.5 D |
From 43.00€
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Item number: Cay14933-10
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC50 = 20 nM). It counteracts SMO activation by the SMO agonist SAG...
Keywords: | N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine |
Application: | SMO antagonist, Hedgehog signaling inhibitor |
CAS | 304909-07-7 |
MW: | 373.5 D |
From 84.00€
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Item number: Cay16164-10
Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of...
Keywords: | 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester |
Application: | SMO agonist |
CAS | 300833-95-8 |
MW: | 450.5 D |
From 114.00€
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Item number: Cay16264-1
LY2940680 is a smoothened (Smo) antagonist. It inhibits [35S]GTPgammaS binding in CHO cells expressing wild-type Smo (IC50 = 294 nM) and reduces production of GLI1 mRNA induced by sonic hedgehog (Shh) in Daoy cells (IC50 = 5.49 nM). Topical application of LY2940680 (2% w/v) decreases skin GLI1 and PTCH1 mRNA...
Keywords: | Taladegib, 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-benzamide |
Application: | Smo inhibitor |
CAS | 1258861-20-9 |
MW: | 512.5 D |
From 82.00€
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