71 products were found matching "K06226"!

Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 µM). It directly binds to SMO and can block SMO inhibition by cyclopamine. Binding of SAG alters the conformation of SMO, leading to its...

Hh-Ag 1. is an agonist of smoothened (Smo) receptor. It induces nuclear glioma-associated oncogene 1 (Gli1) expression in a reporter assay using NIH3T3 cells (EC50 = 0. nM). InChI:...

PF-5274857 is a smoothened receptor (Smo) antagonist. It binds to Smo (Ki = 4. nM) and inhibits transcription of Gli1 in mouse embryonic fibroblasts (MEFs, IC50 = 2. nM). In vivo, PF-5274857 inhibits tumor growth and induces tumor regression in a medulloblastoma mouse allograft model when administered at doses less...

Soluble in water or DMSO. Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations....

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Cyclopamine inhibits activation of the Hedgehog response pathway by binding to and inhibiting the proto-oncogene Smoothened (SMO). The effects of oncogenic mutations that either activate SMO or inactivate the tumor suppressor Patched (Ptch) can be reversed by cyclopamine treatment. Cyclopamine has also been shown to...

Protein function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7,...

Cell permeable smoothened (Smo) agonist - Shown to induce Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo - Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations.

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 µM), and this activation is selective for the...

Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell...

Smo inhibitor.

Soluble in DMSO. Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524).