SA 57

SA 57 is an inhibitor of fatty acid amide hydrolase (FAAH, IC50s = 1.9 and 3.2 nM for hFAAH and mFAAH, respectively), monoacylglycerol lipase (MAGL, IC50s = 1,400 and 410 nM for hMAGL and mMAGL, respectively) and alpha/beta-hydrolase domain-containing protein 6 (mABHD6, IC50 = 850 nM). In vivo, SA 57, at doses >1.25 mg/kg, selectively inactivates mFAAH and, at a dose of 12.5 mg/kg, inactivates mMAGL and mABHD6 resulting in a 10-fold increase in their substrates. Administration of SA 57 (5 mg/kg, i.p.) to morphine-dependent mice alleviates withdrawal signs without eliciting cannabimimetic side effects.Formal Name: 4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylic acid-2-(methylamino), 2-oxoethyl ester. CAS Number: 1346169-63-8. Molecular Formula: C17H23ClN2O3. Formula Weight: 338.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mM, Ethanol: 20 mM. lambdamax: 222 nm. SMILES: ClC1=CC=C(CCC2CCN(C(OCC(N([H])C)=O)=O)CC2)C=C1. InChi Code: InChI=1S/C17H23ClN2O3/c1-19-16(21)12-23-17(22)20-10-8-14(9-11-20)3-2-13-4-6-15(18)7-5-13/h4-7,14H,2-3,8-12H2,1H3,(H,19,21). InChi Key: JFSSVCSHPDLFCM-UHFFFAOYSA-N.