(S)-WAY-100135 (hydrochloride)

(S)-WAY-100135 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 15.5 nM in a radioligand binding assay using rat hippocampus). It is selective for 5-HT1A over 5-HT1B, 5-HT1C, and 5-HT2 receptors, as well as dopamine D1 and D2, and alpha1-, alpha2-, and beta-adrenergic receptors (IC50s = >1 µM for all). (S)-WAY-100135 (10 mg/kg) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.Formal Name: (alphaS)-N-(1,1-dimethylethyl)-4-(2-methoxyphenyl)-alpha-phenyl-1-piperazinepropanamide, dihydrochloride. CAS Number: 149007-54-5. Molecular Formula: C24H33N3O2 . 2HCl. Formula Weight: 468.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Water: 10 mM. SMILES: COC1=C(N2CCN(CC2)C[C@H](C3=CC=CC=C3)C(NC(C)(C)C)=O)C=CC=C1.Cl.Cl. InChi Code: InChI=1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4,,/h5-13,20H,14-18H2,1-4H3,(H,25,28),2*1H/t20-,,/m1../s1. InChi Key: VJGZNBYDSDEOED-FAVHNTAZSA-N.