(S)-5-hydroxy-6-methoxy Duloxetine (maleate)

(S)-5-hydroxy-6-methoxy Duloxetine is an active metabolite of the serotonin (5-HT) and norepinephrine reuptake inhibitor (S)-duloxetine (Cay-14317). It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol duloxetine intermediate. (S)-5-hydroxy-6-methoxy Duloxetine inhibits the 5-HT transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) in lipid membranes (Kis = 266, 920, and 2,814 nM, respectively, for the human transporters).Formal Name: 2-methoxy-5-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]-1-naphthalenol, maleate. Molecular Formula: C19H21NO3S . C4H4O4. Formula Weight: 459.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: OC(/C=C\C(O)=O)=O.CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=C(O)C(OC)=CC=C32. InChi Code: InChI=1S/C19H21NO3S.C4H4O4/c1-20-11-10-16(18-7-4-12-24-18)23-15-6-3-5-14-13(15)8-9-17(22-2)19(14)21,5-3(6)1-2-4(7)8/h3-9,12,16,20-21H,10-11H2,1-2H3,1-2H,(H,5,6)(H,7,8)/b,2-1-/t16-,/m0./s1. InChi Key: KNDHKJRGZZJYIU-ZSJYYTRTSA-N.