140 products were found matching "K05037"!

A SERT, DAT, and NET inhibitor, binds these transporters (Kis = 2.4, 5.2, and 5.4 µM, respectively) and inhibits serotonin, dopamine, and norepinephrine reuptake in intact cells expressing the human transporters (IC50s = 117, 910, and 55 nM, respectively), increases the mechanical withdrawal threshold in a rat model...

A specific serotonin uptake inhibitor. It was found to exert inhibitory or stimulating effects on T-lymphocyte proliferation depending on the concentration.pH value: 5-7 (5% aqueous solution)

An internal standard for the quantification of imipramine by GC- or LC-MS

Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15...

Amitriptyline is a first generation tricyclic antidepressant. It inhibits serotonin (5-HT) uptake by isolated human platelets by 39 and 68% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 77% when administered at a dose of 10 mg/kg. It is also an...

A SERT, DAT, and NET inhibitor, inhibits serotonin, dopamine, and norepinephrine uptake in HEK293 cells expressing human SERT, DAT, and NET (IC50s = 8, 48.2, and 17 µM, respectively). Formulation: A solid. InChI:...

Imipramine is a first generation tricyclic antidepressant. It inhibits serotonin (5-HT) uptake by isolated human platelets by 54 and 79% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 63% when administered at a dose of 20 mg/kg. It also binds to...

Paroxetine is a selective serotonin reuptake inhibitor (SSRI, Ki = 0.04 nM). It is selective for the serotonin transporter (SERT) over the dopamine and norepinephrine transporters (Kis = 400 and 90 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A, the histamine H1 receptor,...

Mesembrine is an alkaloid that has been found in S. tortuosum and has serotonin (5-HT) reuptake inhibitory activity. It selectively binds to the 5-HT transporter (SERT, IC50 = 4.3 µg/ml) over a variety of receptors (IC50s = 148->750 µg/ml). Mesembrine inhibits the reuptake of 5-HT in vitro (Ki = 1.4 nM). It has...

Escitalopram is the S-enantiomer of racemic citalopram, like citalopram, this compound is an SSRI that exhibits antidepressant and anxiolytic qualities and is also effective in treating OCD. Escitalopram inhibits the serotonin transporter (SERT), preventing reuptake of serotonin. Escitalopram may have other...

Clomipramine is a tricyclic antidepressant, the 3-chlorinated derivative of imipramine (Cay-15890). Like imipramine, clomipramine potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM, respectively). It also is an antagonist at histamine, muscarinic acetylcholine, alpha1-adrenergic, and...

Sertraline Hydrochloride is a selective serotonin reuptake inhibitor (SSRI) used as an antidepressant.