113 products were found matching "K05037"!

Dapoxetine-d7 is intended for use as an internal standard for the quantification of dapoxetine by GC- or LC-MS. Dapoxetine is a selective serotonin (5-HT) reuptake inhibitor (SSRI, IC50 = 10 nM in isolated rat cerebral cortex membranes). It selectively inhibits 5-HT uptake over norepinephrine or dopamine uptake in...

Nortriptyline (hydrochloride) (CRM) (Cay-19042) is a certified reference material categorized as an antidepressant. Nortriptyline is an active metabolite of amitriptyline (Cay-19031, Cay-19029). It decreases immobility time in the forced swim test in rats and has antinociceptive activity in mice. Nortriptyline...

(S)-5-hydroxy-6-methoxy Duloxetine is an active metabolite of the serotonin (5-HT) and norepinephrine reuptake inhibitor (S)-duloxetine (Cay-14317). It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol...

Fluoxetine (hydrochloride) (Cay-14418) is an analytical reference material categorized as an antidepressant. This product is intended for research and forensic applications.Formal Name: N-methyl-gamma-[4-(trifluoromethyl)phenoxy]-benzenepropanamine, monohydrochloride. CAS Number: 56296-78-7. Molecular Formula:...

Nortriptyline (hydrochloride) (Cay-19041) is an analytical reference material categorized as an antidepressant. Nortriptyline is an active metabolite of amitriptyline (Cay-19031, Cay-19029). It decreases immobility time in the forced swim test in rats and has antinociceptive activity in mice. Nortriptyline decreases...

Citalopram (hydrobromide) (Cay-23252) is an analytical reference material categorized as an antidepressant. This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Cay-14572).Formal Name:...

BTS-54-505 is an active metabolite of sibutramine. It inhibits norepinephrine, serotonin (5-HT), and dopamine uptake in rat cortical synaptosomes (IC50s = 0.066, 5.1, and 0.61 µM, respectively). In vivo, BTS-54-505 prevents reserpine-induced ptosis in rats (ED50 = 3.7 mg/kg) and decreases immobility in the Porsolt...

A specific serotonin uptake inhibitor. It was found to exert inhibitory or stimulating effects on T-lymphocyte proliferation depending on the concentration.pH value: 5-7 (5% aqueous solution)

Amitriptyline-d3 (hydrochloride) (CRM) (Cay-19033) is intended for use as an internal standard for the quantification of amitriptyline (Cay-19031, Cay-19029) by GC- or LC-MS. Amitriptyline is categorized as a tricyclic antidepressant. This product is intended for research and forensic applications.Formal Name:...

ZZL-7 is an inhibitor of the protein-protein interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS). It increases in vivo serotonergic neuron firing in SERT-Cre transgenic mice, which have reduced SERT levels, when administered at a dose of 10 mg/kg. ZZL-7 (20 and 40 mg/kg)...

Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15...

Amitriptyline is a first generation tricyclic antidepressant. It inhibits serotonin (5-HT) uptake by isolated human platelets by 39 and 68% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 77% when administered at a dose of 10 mg/kg. It is also an...