Ro 90-7501

Ro 90-7501 is a bi-benzimidazole compound that was first found to retard the formation of mature amyloid beta42 fibrils in a cell-based assay. Instead, extended polymeric sheets and fibrillary intermediates of amyloid beta42 accumulated in response to Ro 90-7501 treatment, resulting in reduced cytotoxicity (EC50 = 2 µM). More recently, Ro 90-7501 was shown to modulate signaling in cells stimulated with polyinosinic-polycytidylic acid (poly(I:C), a toll-like receptor 3 (TLR3), and RIG-1-like receptor agonist. Ro 90-7501 (10 µM) enhanced poly(I:C)-induced IFN-beta expression, decreased NF-kappaB activation, and amplified the suppression of vesicular stomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3.Formal Name: 2'-(4-aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine. CAS Number: 293762-45-5. Molecular Formula: C20H16N6. Formula Weight: 340.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, DMSO: 10 mg/ml, Ethanol: 2 mg/ml. lambdamax: 226, 276, 354 nm. SMILES: NC1=CC=C(C2=NC(C=CC(C3=NC4=C(C=CC(N)=C4)N3)=C5)=C5N2)C=C1. InChi Code: InChI=1S/C20H16N6/c21-13-4-1-11(2-5-13)19-23-15-7-3-12(9-17(15)25-19)20-24-16-8-6-14(22)10-18(16)26-20/h1-10H,21-22H2,(H,23,25)(H,24,26). InChi Key: PAGZCEHLFCJSPV-UHFFFAOYSA-N.