Ro 67-4853

Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1), enhancing glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors (pEC50 = 7.16). While only mildly potentiating mGluR5 signaling, this compound is without effect at mGluR2, mGluR4, or mGluR8, as well as at several other neural receptors. Ro 67-4853 can also directly activate mGluR1 signaling in baby hamster kidney cells, leading to phosphorylation of ERK1/2 (EC50 = 6.2 nM) and activation of adenylate cyclase (EC50 = 11.7 µM). Ro 67-4853 can also be used to enhance neuronal stimulation in response to the mGluR1/mGluR5 agonist DHPG, both in vivo and in vitro (EC50 = 95 nM).Formal Name: N-(9H-xanthen-9-ylcarbonyl)-carbamic acid, butyl ester. CAS Number: 302841-89-0. Molecular Formula: C19H19NO4. Formula Weight: 325.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.50 mg/ml. lambdamax: 204, 242, 283 nm. SMILES: O=C(NC(OCCCC)=O)C1C2=CC=CC=C2OC3=C1C=CC=C3. InChi Code: InChI=1S/C19H19NO4/c1-2-3-12-23-19(22)20-18(21)17-13-8-4-6-10-15(13)24-16-11-7-5-9-14(16)17/h4-11,17H,2-3,12H2,1H3,(H,20,21,22). InChi Key: RQBUXEUMZZQUFY-UHFFFAOYSA-N.