RN-1747

RN-1747 is an agonist of transient receptor potential vanilloid 4 (TRPV4). It selectively induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPV4 (EC50s = 0.77, 4.1, and 4 µM, respectively) over HEK293 cells expressing human TRPV1, TRPV3, or transient receptor potential melastatin 8 (TRPM8, EC50s = >100, >30, and >30 µM, respectively). RN-1747 (10 µM) induces inward current in Xenopus oocytes expressing human TRPV4. Topical, but not intravenous, administration of RN-1747 induces hypothermia in rats.Formal Name: 1-[(4-chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine. CAS Number: 1024448-59-6. Molecular Formula: C17H18ClN3O4S. Formula Weight: 395.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: ClC1=CC=C(S(=O)(N2CCN(CC2)CC3=CC=CC=C3)=O)C([N+]([O-])=O)=C1. InChi Code: InChI=1S/C17H18ClN3O4S/c18-15-6-7-17(16(12-15)21(22)23)26(24,25)20-10-8-19(9-11-20)13-14-4-2-1-3-5-14/h1-7,12H,8-11,13H2. InChi Key: ZNLVYSJQUMALEO-UHFFFAOYSA-N.