- Search results for K04973
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30 products were found matching "K04973"!
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Item number: ELK-ELK0818.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TRPV4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TRPV4. Next,...
Keywords: | TrpV4, Vroac, Trpv4, VR-OAC, OTRPC4, Osm-9-like TRP channel 4, Vanilloid receptor-related osmotically-activated channel,... |
Application: | ELISA |
Species reactivity: | rat |
From 365.00€
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Item number: Cay37573-10
RN-1747 is an agonist of transient receptor potential vanilloid 4 (TRPV4). It selectively induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPV4 (EC50s = 0.77, 4.1, and 4 µM, respectively) over HEK293 cells expressing human TRPV1, TRPV3, or transient receptor potential melastatin 8 (TRPM8,...
Keywords: | 1-[(4-chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine |
Application: | TRPV4 agonist |
CAS | 1024448-59-6 |
MW: | 395.9 D |
From 104.00€
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Item number: Cay17289-5
Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel thought to be involved in osmoregulation, hyperalgesia, and control of epithelial cell volume. GSK1016790A is a TRPV4 agonist that has been reported to elicit calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and...
Keywords: | N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]-... |
Application: | TRPV4 agonist |
CAS | 942206-85-1 |
MW: | 655.6 D |
From 43.00€
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Item number: Cay17715-5
GSK2193874 is a potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC50 values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively. It is selective for TRPV4 over ~200 other human receptors, channels, and enzymes. GSK2193874 is effective in...
Keywords: | 3-([1,4'-bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide |
Application: | TRPV4 antagonist |
CAS | 1336960-13-4 |
MW: | 691.6 D |
From 43.00€
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Item number: AG-CN2-0082-M001
Semi-synthetic. Negative control for phorbol ester activation of protein kinase C and studies with PMA (AG-CN2-0010). Might be a reasonable PKC-independent TRPV4 channels agonist.
Keywords: | 4alpha-PMA, 4alpha-TPA, 4alpha-12-O-Tetradecanoylphorbol 13-acetate |
Application: | TRPV4 channels agonist |
CAS | 63597-44-4 |
MW: | 616,8 D |
72.00€
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Item number: Cay20927-5
HC-067047 is a TRPV4 antagonist that reversibly inhibits currents through human, rat, and mouse TRPV4 orthologs (IC50s = 48, 133, and 17 nM, respectively). It is selective for TRPV4 over TRPV1, TRPV2, TRPV3, and TRPM8 channels. HC-067047 has been shown to increase functional bladder capacity and to reduce...
Keywords: | 2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide |
Application: | TRPV4 antagonist |
CAS | 883031-03-6 |
MW: | 471.5 D |
From 43.00€
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Item number: Cay20446-1
4alpha-Phorbol 12,13-didecanoate is a negative control for phorbol esters, phorbol 12-myristate 13-acetate (PMA, Cay-10008014) and phorbol 12,13-didecanoate (PDD). Though inactive for signaling through PKC, 4alpha-phorbol 12,13-didecanoate has been shown to activate transient receptor potential vanilloid 4 (TRPV4)...
Keywords: | 4alpha-PDD, 4alpha-Phorbol 12,13-dicaprinate, decanoic acid,... |
Application: | Phorbol ester negative control, TRPV4 agonist |
CAS | 27536-56-7 |
MW: | 672.9 D |
From 134.00€
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Item number: Cay24205-5
RN-1734 is a transient receptor potential vanilloid 4 (TRPV4) antagonist, blocking calcium influx induced by the TRPV4 agonist 4alpha-phorbol 12,13-didecanoate (Cay-20446) with IC50 values of 2.3, 5.9, and 3.2 µM for human, mouse, and rat TRPV4, respectively. It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8...
Keywords: | 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-benzenesulfonamide |
Application: | TRPV4 antagonist |
CAS | 946387-07-1 |
MW: | 353.3 D |
From 82.00€
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Item number: NSJ-F46973-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in...
Keywords: | Anti-VRL2, Anti-TrpV4, Anti-VRL-2, Anti-TRPV4, Anti-TRP12, Anti-VR-OAC, Anti-OTRPC4, Anti-Osm-9-like TRP channel 4,... |
Application: | WB, ELISA |
Host: | Rabbit |
Species reactivity: | human |
From 326.00€
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Item number: ARG57869.50
Protein function: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol...
Keywords: | Anti-VRL2, Anti-VRL-2, Anti-TrpV4, Anti-TRPV4, Anti-TRP12, Anti-OTRPC4, Anti-VR-OAC, Anti-Osm-9-like TRP channel 4,... |
Application: | IHC (paraffin), WB |
Host: | Rabbit |
Species reactivity: | human |
520.00€
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Item number: E-AB-10664.120
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure....
Keywords: | Anti-VRL2, Anti-VRL-2, Anti-TrpV4, Anti-TRP12, Anti-TRPV4, Anti-OTRPC4, Anti-VR-OAC, Anti-Osm-9-like TRP channel 4,... |
Application: | IHC, ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 71.00€
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Item number: E-AB-14424.120
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure....
Keywords: | Anti-VRL2, Anti-VRL-2, Anti-TrpV4, Anti-TRP12, Anti-TRPV4, Anti-OTRPC4, Anti-VR-OAC, Anti-Osm-9-like TRP channel 4,... |
Application: | IHC, ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 71.00€
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