RIPA-56

RIPA-56 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1, IC50 = 13 nM). It is selective for RIPK1 over RIPK3 at 10 µM, as well as over a panel of additional kinases at 2 µM. RIPA-56 inhibits Z-VAD-FMK-induced necrosis in HT-29 cells (EC50 = 28 nM). In vivo, RIPA-56 (6 mg/kg) reduces TNF-alpha-induced lethality and protects against TNF-alpha-induced organ damage in a mouse model of systemic inflammatory response syndrome (SIRS). It reduces spinal cord demyelination and breakdown of the blood-brain barrier (BBB) in a mouse model of experimental autoimmune encephalomyelitis (EAE). RIPA-56 (300 mg/kg) reduces hepatic inflammatory cell infiltration and fibrosis, as well as body weight gain and total fat mass, in a mouse model of high-fat diet-induced non-alcoholic steatohepatitis (NASH).Formal Name: N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-butanamide. CAS Number: 1956370-21-0. Molecular Formula: C13H19NO2. Formula Weight: 221.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: O=C(C(C)(CC)C)N(CC1=CC=CC=C1)O. InChi Code: InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3. InChi Key: AVYVHIKSFXVDBG-UHFFFAOYSA-N.