106 products were found matching "K02861"!

ATP + a protein = ADP + a phosphoprotein.,Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation...

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-alpha (TNF-alpha) induced...

(±)-Necrostatin-2 is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation in vitro in a dose-dependent manner. Treatment with 6 mg/kg/day of (±)-necrostatin-2 prevents TNF-induced mortality in a murine model of systemic inflammatory response syndrome (SIRS)....

Necrostatin-1 Inactive Control (Nec-1i) is a demethylated variant of necrostatin-1 (Nec-1, Cay-11658), a RIP1 kinase inhibitor. While both Nec-1 and Nec-1i inhibit the immune regulator indoleamine 2,3-dioxygenase, Nec1i is ~100-fold less effective than Nec-1 in inhibiting RIP1 kinase in vitro and 10-fold less potent...

Human RIPK1, also known as RCK and MAP3K19, GenBank Accession No. NM_003804, a.a. 1-327, with N-terminal GST-tag, MW=63 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.

Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:12654725, PubMed:19590578). Upon activation of TNFR1 by the TNF-alpha family cytokines,...

Necrostatin-5 is a RIP1 kinase inhibitor. It inhibits phosphorylation of RIP1 in Jurkat cells when used at concentrations of 10 and 30 µM. Necrostatin-5 inhibits TNF-alpha-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD, EC50 = 0.24 µM), a modification that prevents caspase...

GSK481 is an inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1 or RIPK1) that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM. It is selective for RIP1 over a panel of over 450 other kinases, including RIP3. GSK481 inhibits RIP1 from human and...

Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1). It inhibits RIPK1 activity when used at concentrations of 0.3, 3, and 30 µM. It also inhibits TNF-alpha-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD, EC50 = 180 nM), a modification that...

Anti-RIP1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with RIP1 from other sources has not been determined. Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors...

Protein function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1...

GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1, IC50s = 16 and 2,500 nM for the human and mouse enzymes, respectively). It is greater than 10,000-fold selective for RIPK1 over a panel of 339 kinases at 10 µM. GSK2982772 inhibits necrotic cell death induced by a combination of...