Rasagiline-13C3 (mesylate)

Rasagiline-13C3 is intended for use as an internal standard for the quantification of rasagiline (Cay-14917) by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B, IC50 = 4.43 nM for the rat brain enzyme). It is selective for MAO-B over MAO-A (IC50 = 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 µM. Rasagiline inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg). It reduces cerebral edema in a mouse model of traumatic brain injury. Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces alpha-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson's disease. Formulations containing rasagiline have been used in the treatment of Parkinson's disease.Formal Name: (R)-N-(prop-2-yn-1-yl-13C3)-2,3-dihydro-1H-inden-1-amine, monomethanesulfonate. CAS Number: 1391052-18-8. Molecular Formula: C9[13C]3H13N . CH3SO3H. Formula Weight: 270.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Slightly soluble. SMILES: CS(=O)(O)=O.[13CH]#[13C][13CH2]N[C@H]1C2=CC=CC=C2CC1. InChi Code: InChI=1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12,1-5(2,3)4/h1,3-6,12-13H,7-9H2,1H3,(H,2,3,4)/t12-,/m1./s1/i1+1,2+1,9+1,. InChi Key: JDBJJCWRXSVHOQ-UAWGACSXSA-N.