159 products were found matching "K00274"!

Monoamine oxidase A (MAO-A), a mitochondrial enzyme, catalyzes the degradation of monoamines. Studies show that increased expression of MAO-A promotes prostate cancer metastasis by activating the Shh-IL6-RANKL signaling network. In addition, MAO-A expression in adipose tissue macrophages is upregulated in aging,...

Bifemelane is an inhibitor of monoamine oxidase A (MAO-A, Ki = 4.2 µM). It is selective for MAO-A over MAO-B (Ki = 46 µM). Bifemelane (15 mg/kg, p.o.) protects against ischemia-induced decreases in frontal cortex, hippocampus, and striatum levels of muscarinic acetylcholine receptors (mAChRs) in a rat model of...

An LSD1 and MAO-B inhibitor (IC50s = 0.101 and 0.073 µM, respectively), selective for LSD1 and MAO-B over MAO-A (IC50 = 5.47 µM) and LSD2, SMOX, and LAAO at 10 µM, as well as a panel of 19 additional epigenetic targets and a panel of 92 receptors, ion channels, enzymes, and transporters at 10 µM, induces...

An inhibitor of MAO-A (IC50 = 0.43 µM), selective for MAO-A over MAO-B, decreases immobility time in the forced swim test in mice at 50 mg/kg, inhibits reserpine-induced palpebral ptosis in mice at 25 mg/kg

A selective and reversible MAO-A inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively), selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively), reverses the depressive-like effects induced by CMS, increases hippocampal cell proliferation,...

Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 µg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 µM in HCT116...

Phenelzine is an inhibitor of monoamine oxidase (MAO, IC50 = 0.9 µM using rat brain mitochondrial preparations). It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine,...

Isoniazid is an antibiotic that acts as a prodrug, being converted by bacterial catalase-peroxidases to form isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis. It is effective against several species of Mycobacterium, including M. tuberculosis.Formal Name: 4-pyridinecarboxylic acid, hydrazide....

Safinamide is an inhibitor of monoamine oxidase B (MAO-B, IC50 = ~0.1 µM). It is selective for MAO-B over MAO-A (IC50 = >10 µM). It also inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 µM, respectively). Safinamide...

Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression. R-(-)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 µM) over MAO-A (Ki = 9.06 µM). In addition to finding use against depression, R-(-)-deprenyl provides neuroprotection...

Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin (Cay-14332) receptors, but it does inhibit the sigma receptor sigma1 on Jurkat human T lymphocyte...

Monoamine oxidases (MAO) are a family of flavin-containing amine oxidoreductases that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in numerous tissues including liver, intestinal mucosa, and nerves. In humans there are two types of MAO: MAO-A and MAO-B. MAO-A is...