177 products were found matching "K00274"!

Iproniazid is an inhibitor of monoamine oxidase A (MAO-A) and MAO-B (IC50s = 6.56 and 7.54 µM, respectively). It reduces immobility in an open swimming test in rats, indicating antidepressant-like activity, when administered at a dose of 10 mg/kg. Iproniazid (300 and 400 mg/kg) induces acute hepatic necrosis in...

Monoamine oxidase A (MAO-A), a mitochondrial enzyme, catalyzes the degradation of monoamines. Studies show that increased expression of MAO-A promotes prostate cancer metastasis by activating the Shh-IL6-RANKL signaling network. In addition, MAO-A expression in adipose tissue macrophages is upregulated in aging,...

Bifemelane is an inhibitor of monoamine oxidase A (MAO-A, Ki = 4.2 µM). It is selective for MAO-A over MAO-B (Ki = 46 µM). Bifemelane (15 mg/kg, p.o.) protects against ischemia-induced decreases in frontal cortex, hippocampus, and striatum levels of muscarinic acetylcholine receptors (mAChRs) in a rat model of...

A selective and reversible MAO-A inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively), selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively), reverses the depressive-like effects induced by CMS, increases hippocampal cell proliferation,...

An LSD1 and MAO-B inhibitor (IC50s = 0.101 and 0.073 µM, respectively), selective for LSD1 and MAO-B over MAO-A (IC50 = 5.47 µM) and LSD2, SMOX, and LAAO at 10 µM, as well as a panel of 19 additional epigenetic targets and a panel of 92 receptors, ion channels, enzymes, and transporters at 10 µM, induces...

An inhibitor of MAO-A (IC50 = 0.43 µM), selective for MAO-A over MAO-B, decreases immobility time in the forced swim test in mice at 50 mg/kg, inhibits reserpine-induced palpebral ptosis in mice at 25 mg/kg

Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 µg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 µM in HCT116...

Phenelzine is an inhibitor of monoamine oxidase (MAO, IC50 = 0.9 µM using rat brain mitochondrial preparations). It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine,...

Isoniazid is an antibiotic that acts as a prodrug, being converted by bacterial catalase-peroxidases to form isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis. It is effective against several species of Mycobacterium, including M. tuberculosis.Formal Name: 4-pyridinecarboxylic acid, hydrazide....

Safinamide is an inhibitor of monoamine oxidase B (MAO-B, IC50 = ~0.1 µM). It is selective for MAO-B over MAO-A (IC50 = >10 µM). It also inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 µM, respectively). Safinamide...

Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions, including depression. R-(-)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 µM) over MAO-A (Ki = 9.06 µM). In addition to finding use against depression, R-(-)-deprenyl provides neuroprotection...

Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin (Cay-14332) receptors, but it does inhibit the sigma receptor sigma1 on Jurkat human T lymphocyte...