Raloxifene-d4 (hydrochloride)

Raloxifene-d4 is intended for use as an internal standard for the quantification of raloxifene (Cay-10011620) by GC- or LC-MS. Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits estrogenic activity in bone cells without stimulating breast or uterine tissues. Raloxifene guards endothelial cells obtained from rat aortic rings against oxidative insult (1 µM) and lowers serum cholesterol in ovariectomized rodents (ED50 = 0.2 mg/kg). Formulations containing raloxifene have been shown to reduce bone resorption and promote bone formation in post-menopausal women.Formal Name: (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy-1,1,2,2-d4)phenyl)methanone hydrochloride. CAS Number: 1188263-47-9. Molecular Formula: C28H23D4NO4S . HCl. Formula Weight: 514.1. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: OC1=CC=C(C(C(C2=CC=C(OC([2H])([2H])C([2H])([2H])N3CCCCC3)C=C2)=O)=C(C4=CC=C(O)C=C4)S5)C5=C1.Cl. InChi Code: InChI=1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29,/h4-13,18,30-31H,1-3,14-17H2,1H/i16D2,17D2,. InChi Key: BKXVVCILCIUCLG-ZBLPOJTCSA-N.