RAF265

RAF265 is a dual inhibitor of mutant B-RafV600E and vascular endothelial growth factor receptor 2 (EC50s = 0.14 and 0.19 µM, respectively, in cell-based assays). It can also inhibit wild-type B-Raf, platelet-derived growth factor receptor, colony-stimulating factor 1R, RET, c-KIT, SRC, and STE20 with IC50 values ranging from 20-100 nM. RAF265 can inhibit proliferation of melanoma and colorectal cancer cell lines with active BRAF mutations as well as suppress tumor growth in melanoma xenograft models bearing B-RafV600E mutations.Formal Name: 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine. CAS Number: 927880-90-8. Synonyms: CHIR265. Molecular Formula: C24H16F6N6O. Formula Weight: 518.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 210, 266, 314 nm. SMILES: CN1C(NC2=CC=C(C(F)(F)F)C=C2)=NC3=C1C=CC(OC4=CC=NC(C5=NC=C(C(F)(F)F)N5)=C4)=C3. InChi Code: InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34). InChi Key: YABJJWZLRMPFSI-UHFFFAOYSA-N.