R-848

R-848 is an immune response modifier that mimics the pathogen-associated molecular patterns that activate immune cells through Toll-like receptor 7 (TLR7) and TLR8. It demonstrates potent anti-tumor and anti-viral properties and has been used to study the innate immune response to viral infections. At 1 µg/ml, R-848 mimics CD40-induced B cell activation and can be used to induce the production of IFN-gamma and various other cytokines.Formal Name: 4-amino-2-(ethoxymethyl)-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol. CAS Number: 144875-48-9. Synonyms: Resiquimod, S 28463. Molecular Formula: C17H22N4O2. Formula Weight: 314.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 12.5 mg/ml, Ethanol: 3.3 mg/ml. lambdamax: 249, 328 nm. SMILES: NC1=NC2=CC=CC=C2C3=C1N=C(COCC)N3CC(C)(C)O. InChi Code: InChI=1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19). InChi Key: BXNMTOQRYBFHNZ-UHFFFAOYSA-N.