105 products were found matching "K05404"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TLR7. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TLR7. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TLR7. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TLR7. Next,...

The TLR7 (Toll-like receptor 7)/NF-kappaB Luciferase Reporter HEK293 Cell Line is a HEK293 cell line that expresses the Firefly luciferase reporter under the control of NF-kappaB (nuclear factor kappaB) response element, human TLR7 (Toll-like receptor 7) (NM_016562.4), and a mutated version of the chaperone protein...

Imiquimod is an imidazoquinoline agonist of toll-like receptor 7 (TLR7, EC50 = 2.12 µM). It increases TNF-alpha and IL-12 p40 production in IFN-gamma-treated murine peritoneal macrophages in a concentration- and MyD88-dependent manner. Topical application of imiquimod (30 µl of 5% cream) increases TNF and IFN levels...

GS-9620 is an orally available agonist of toll-like receptor 7 (TLR7, EC50 = 291 nM) with 30-fold selectivity over TLR8 (EC50 = 9 µM). It has been shown to stimulate a TLR7 immune response in two different animal models of chronic hepatitis B infection and to inhibit HIV-1 infection in human peripheral blood...

Synthetic. Immune response modifier. Potent antitumor and antiviral compound. Stimulates antibody secretion and cytokine production. Used as adjuvant to increase the effectiveness of vaccines. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Activates...

Gardiquimod is an agonist of human toll-like receptor 7 (TLR7), but not human TLR8, although it activates both porcine TLR7 and TLR8. At 0.5 to 2 µg/ml, it enhances the immunosuppressive activity of T regulatory cells. Gardiquimod is effective as a mucosal adjuvant for Norwalk virus-like particles and inhibits...

Immune response modulator. Anti-inflammatory. TLR7 agonist. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound....

Imiquimod-d9 is intended for use as an internal standard for the quantification of imiquimod (Cay-14956) by GC- or LC-MS. Imiquimod is an imidazoquinoline agonist of toll-like receptor 7 (TLR7, EC50 = 2.12 µM). It increases TNF-alpha and IL-12 p40 production in IFN-gamma-treated murine peritoneal macrophages in a...

Synthetic. Immune response modifier. Antiviral and antitumor compound Selective ligand for human or mouse Toll-like receptor 7 (TLR7). Induces the activation of NF-kappaB in HEK 293 cells expressing TLR7 at 0.1µg/ml. 10 times more active than Imiquimod (Prod. No. AG-CR1-3569). At high concentrations (3µg/ml)...

R-848 is an immune response modifier that mimics the pathogen-associated molecular patterns that activate immune cells through Toll-like receptor 7 (TLR7) and TLR8. It demonstrates potent anti-tumor and anti-viral properties and has been used to study the innate immune response to viral infections. At 1 µg/ml,...

Loxoribine is a guanosine derivative and an agonist of toll-like receptor 7 (TLR7). It is selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM.. Loxoribine induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against...