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R-7050 is a cell-permeable antagonist of signaling through the TNF-alpha receptor complex (EC50 = 0.631 µM). It blocks TNF-alpha-induced binding of TNF-alpha receptor I with TNF-alpha receptor-associated death domain protein and receptor interacting protein 1, which, in turn, prevents internalization of the receptor complex. R-7050 is 2.3-fold more selective for TNF-alpha-mediated signaling than for that driven by IL-1beta. It has been used to investigate the role of TNF-alpha in neurovascular injury and mycotoxin-induced anorexia.Formal Name: 8-chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline. CAS Number: 303997-35-5. Synonyms: TNF-alpha Antagonist III. Molecular Formula: C16H8ClF3N4S. Formula Weight: 380.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 1 mg/ml. lambdamax: 220, 310, 325, 340 nm. SMILES: ClC1=CC(N2C3=NN=C2C(F)(F)F)=C(C=C1)N=C3SC4=CC=CC=C4. InChi Code: InChI=1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H. InChi Key: SUUMKHOVGVYGOP-UHFFFAOYSA-N.
Keywords:
TNF-alpha Antagonist III, 8-chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
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