R-268712

R-268712 is an inhibitor of activin receptor-like kinase (ALK5, IC50 = 2.5 nM). It is selective for ALK5 over p38 MAPK (IC50 = 12 µM). R-268712 (1, 3, and 10 mg/kg) reduces renal fibrosis in a model of unilateral ureteral obstruction using transgenic Col1a1-Luc Tg rats, a reporter model for collagen I expression. It also reduces proteinuria and glomerulosclerosis and improves renal function in heminephrectomized rats in a model of glomerulonephritis using antibodies against Thy-1 membrane glycoprotein when administered at doses of 0.3 and 1 mg/kg.Formal Name: 4-[2-fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol. CAS Number: 879487-87-3. Molecular Formula: C20H18FN5O. Formula Weight: 363.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml. lambdamax: 230, 252, 290 nm. SMILES: FC(C=C1)=C(C2=CN(CCO)N=C2)C=C1C3=CNN=C3C4=NC(C)=CC=C4. InChi Code: InChI=1S/C20H18FN5O/c1-13-3-2-4-19(24-13)20-17(11-22-25-20)14-5-6-18(21)16(9-14)15-10-23-26(12-15)7-8-27/h2-6,9-12,27H,7-8H2,1H3,(H,22,25). InChi Key: JQGOCCALXFSRHZ-UHFFFAOYSA-N.