- Search results for K04674
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79 products were found matching "K04674"!
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Item number: Cay13031-25
SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...
Keywords: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate |
Application: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
MW: | 384.4 D |
From 43.00€
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Item number: ELK-ELK1441.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TGFbR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TGFbR1....
Keywords: | ALK5, SKR4, ALK-5, TGFBR1, TGFR-1, TbetaR-I, EC=2.7.11.30, TGF-beta type I receptor, TGF-beta receptor type-1, TGF-beta... |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: ELK-ELK4572.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TGFbR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TGFbR1....
Keywords: | ESK2, TGFR-1, Tgfbr1, TbetaR-I, EC=2.7.11.30, TGF-beta receptor type-1, TGF-beta receptor type I, Transforming growth... |
Application: | ELISA |
Species reactivity: | mouse |
From 365.00€
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Item number: Cay14794-25
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
Keywords: | E 616452, RepSox, SJN 2511, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
Application: | ALK5 inhibitor |
CAS | 446859-33-2 |
MW: | 287.3 D |
From 35.00€
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Item number: Cay36810-10
R-268712 is an inhibitor of activin receptor-like kinase (ALK5, IC50 = 2.5 nM). It is selective for ALK5 over p38 MAPK (IC50 = 12 µM). R-268712 (1, 3, and 10 mg/kg) reduces renal fibrosis in a model of unilateral ureteral obstruction using transgenic Col1a1-Luc Tg rats, a reporter model for collagen I expression. It...
Keywords: | 4-[2-fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol |
Application: | TGF-beta receptor type-1 (ALK5) inhibitor |
CAS | 879487-87-3 |
MW: | 363.4 D |
From 35.00€
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Item number: Cay9001799-10
A 83-01 is an inhibitor of TGF-beta type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-beta-induced epithelial-to-mesenchymal transition. It has little effect on bone...
Keywords: | 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
Application: | TGFBR1 inhibitor |
CAS | 909910-43-6 |
MW: | 421.5 D |
From 39.00€
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Item number: Cay15312-1
LY2157299 is a small molecule inhibitor of the TGF-beta receptor type 1 kinase (IC50 = 56 nM). It has been used to study the role of TGF-beta signaling in chemotherapy-induced expansion of cancer stem-like cells in triple negative breast cancer cell lines and xenografts. LY2157299 has also been shown to inhibit the...
Keywords: | Galunisertib, 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide |
Application: | TGFBR1 inhibitor |
CAS | 700874-72-2 |
MW: | 369.4 D |
From 66.00€
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Item number: Cay37777-1
BIBF 0775 is an inhibitor of TGF-beta receptor type 1 (ALK5, IC50 = 34 nM). It is selective for ALK5 over VEGFR2 and PDGFRalpha (IC50s = 1,447 and 890 nM, respectively), as well as a panel of 30 other kinases at 1 µM. BIBF 0775 inhibits the phosphorylation of SMAD2 and SMAD3 in HaCaT cells (EC50 = 105 nM) and is not...
Keywords: | (3Z)-N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide |
Application: | ALK5 inhibitor |
CAS | 334951-90-5 |
MW: | 494.6 D |
From 50.00€
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Item number: 600-401-MG6
This affinity purified antibody is directed against human TGF beta receptor type-1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to...
Keywords: | Anti-ALK5, Anti-SKR4, Anti-ALK-5, Anti-TGFBR1, Anti-TGFR-1, Anti-TbetaR-I, EC=2.7.11.30, Anti-TGF-beta receptor type-1,... |
Application: | ELISA, FC, IHC, IF, WB |
Host: | Rabbit |
Species reactivity: | human, mouse |
647.00€
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Item number: LKT-S0400.1
SB-431542 inhibits activin receptor-like kinases ALK4, ALK5, and ALK7, this inhibition leads to inhibition of activin and TGF- signaling with no downstream effects on ERK, JNK, or MAPK. SB-431542 exhibits anti-angiogenic and anticancer activity. In vitro, SB-431542 inhibits proliferation and motility of glioma...
Application: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
CAS | 301836-41-9 |
MW: | 384.39 D |
From 94.00€
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Item number: Cay13341-5
Transforming growth factor-beta (TGF-beta) signals through a cell surface heteromeric complex involving type I (TGF-beta RI) and type II (TGF-beta RII) receptors. Downstream signal transduction is mediated by the TGF-beta RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective...
Keywords: | HTS 466284, TGF-beta RI Kinase Inhibitor, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline |
Application: | TGFbetaRI inhibitor |
CAS | 396129-53-6 |
MW: | 272.3 D |
From 123.00€
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Item number: Cay15409-5
LY2157299 is a small molecule inhibitor of the TGF-beta receptor type 1/type II kinases (IC50 = 69 nM). It has been used to study the role of TGF-beta signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 µM of the compound completely disrupts Smad-2 phosphorylation, an immediate...
Keywords: | 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-quinoline |
Application: | TGFBR1/2 inhibitor |
CAS | 700874-71-1 |
MW: | 441.5 D |
From 60.00€
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