111 products were found matching "K04674"!
No results were found for the filter!
SB-431542 (hydrate)
Item number: Cay13031-25
SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...
| Keywords: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate |
| Application: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| MW: | 384.4 D |
From 44.00€
*
ALK5 Inhibitor II
Item number: Cay14794-25
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
| Keywords: | E 616452, RepSox, SJN 2511, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
| Application: | ALK5 inhibitor |
| CAS | 446859-33-2 |
| MW: | 287.3 D |
From 36.00€
*
SB 525334
Item number: TGM-T1763-5mg
Description: SB-525334 is a potent and selective inhibitor of the TGF-beta1R and ALK5 (IC50: 14.3 nM). Target: ALK, TGF-beta/Smad. Smiles: C(C)(C)(C)C=1NC(=C(N1)C=2N=C(C)C=CC2)C3=CC4=C(C=C3)N=CC=N4. References: Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth...
| Keywords: | SB525334 |
| Application: | TGFBR1 inhibitor |
| CAS | 356559-20-1 |
| MW: | 343.42 D |
From 33.00€
*
TGFBR1 Protein, Mouse, Recombinant (hFc)
Item number: TGM-TMPJ-01178-10ug
Description: TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3....
| Keywords: | AAT5, tbetaR-I, TGF-beta receptor type I, SKR4, TGFBR1, TGFR-1, ACVRLK4, LDS2A, TGF-bRI, TGFB1R1, TGFbetaRI, LDS1A,... |
| MW: | 60 kD |
From 140.00€
*
TGFBR1 Protein, Human, Recombinant (mFc & Avi)
Item number: TGM-TMPK-00305-100ug
Description: transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR-98-5p. miR-98-5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299...
| Keywords: | TGFbetaRI, TGFbetaRI, tbetaR-I, ALK-5, LDS2A, TGFR-1, tbetaR-I, TGF-beta RI, TGF-beta RI, SKR4, TGF-bRI, ACVRLK4, LDS1A,... |
| MW: | 38.2 kD |
From 627.00€
*
TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated
Item number: TGM-TMPK-00306-100ug
Description: transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR-98-5p. miR-98-5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299...
| Keywords: | LDS1A, AAT5, tbetaR-I, TGF-bRI, tbetaR-I, LDS2A, SKR4, TGFB1R1, TGFbetaRI, TGFBR1, ALK-5, TGFbetaRI, TGF-beta RI, TGF-beta... |
| MW: | 38.2 kD |
From 814.00€
*
ALK-5 Protein, Human, Recombinant (His & hFc)
Item number: TGM-TMPY-01358-100ug
Description: ALK-5 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36897-1.
| Keywords: | MSSE, transforming growth factor, beta receptor 1, ESS1, tbetaR-I, ALK-5, SKR4, LDS1A, ACVRLK4, transforming growth... |
| MW: | 38.1 kD |
497.00€
*
ALK-5 Protein, Human, Recombinant (hFc)
Item number: TGM-TMPY-05771-1mg
Description: ALK-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.87 kDa and the accession number is P36897-1.
| Keywords: | AAT5, TGFR-1, SKR4, LDS1, transforming growth factor, beta receptor 1, transforming growth factor, beta receptor 1, ESS1,... |
| MW: | 36.87 kD |
From 355.00€
*
ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)
Item number: TGM-TMPY-04366-50ug
Description: ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 62.6 kDa and the accession number is P36897-1.
| Keywords: | LDS2A, AAT5, ALK-5, SKR4, transforming growth factor, beta receptor 1, tbetaR-I, ESS1, LDS1, tbetaR-I, TGFR-1, ALK5, MSSE,... |
| MW: | 62.6 kD |
497.00€
*
GW788388
Item number: TGM-T1800-100mg
Description: GW788388 is a potent and selective inhibitor of ALK5, and it also inhibits TGF-(beta) type II receptor and activin type II receptor activities. Target: ALK, TGF-beta/Smad. Smiles: O=C(NC1CCOCC1)c1ccc(cc1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1. References: Gellibert F, et al. J Med Chem. 2006, 49(7), 2210-2221.
| Keywords: | GW 788388 |
| Application: | TGFBR1 / ALK5 inhibitor |
| CAS | 452342-67-5 |
| MW: | 425.48 D |
From 58.00€
*
Vactosertib
Item number: TGM-T6496-100mg
Description: Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potential antineoplastic activity. Target: TGF-beta/Smad, ALK. Smiles:...
| Keywords: | TEW-7197, EW-7197 |
| Application: | ALK5 inhibitor |
| CAS | 1352608-82-2 |
| MW: | 399.42 D |
From 40.00€
*
RepSox
Item number: TGM-T6337-100mg
Description: RepSox (ALK5 Inhibitor II) is a TGFbetaR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells. Target: TGF-beta/Smad, ALK. Smiles: Cc1cccc(n1)-c1n[nH]cc1-c1ccc2ncccc2n1. References: Tu WZ, et...
| Keywords: | ALK5 Inhibitor II, E-616452, SJN 2511 |
| Application: | ALK5 inhibitor |
| CAS | 446859-33-2 |
| MW: | 287.32 D |
From 31.00€
*