QNZ 46

QNZ 46 is an antagonist of NR2C- and NR2D-subunit containing NMDA receptors (IC50s = 6 and 3 µM, respectively, for receptors expressed in Xenopus oocytes). It is selective for NR2C- and NR2D-subunit containing NMDA receptors over receptors containing NR2A and NR2B subunits as well as over the AMPA receptor GluR1 (IC50s = 229, >300, and >300 µM, respectively). QNZ 46 acts in a noncompetitive and voltage-independent fashion that requires glutamate but not glycine binding for its activity.Formal Name: 4-[6-methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-benzoic acid. CAS Number: 1237744-13-6. Molecular Formula: C24H17N3O6. Formula Weight: 443.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 228, 346 nm. SMILES: O=C1C2=CC(OC)=CC=C2N=C(/C=C/C3=CC([N+]([O-])=O)=CC=C3)N1C4=CC=C(C(O)=O)C=C4. InChi Code: InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+. InChi Key: GNLVJIICVWDSNI-LFYBBSHMSA-N.