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Pterostilbene is a polyketide synthase-derived stilbene originally isolated from P. santalinus that has diverse biological activities. It reduces photooxidative leakage induced by the herbicide acifluorfen in C. sativus cotyledon disks when used at a concentration of 30 µg/ml. Pterostilbene (25 and 50 µM) inhibits invasion and migration of HepG2 hepatoma cells induced by 12-O-tetradecanoylphorbol 13-acetate (TPA, Cay-10008014). It inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010) in LPS-stimulated RAW 264.7 macrophages when used at concentrations of 10 and 20 µM. Pterostilbene (100 and 300 µM) activates peroxisome proliferator-activated receptor alpha (PPARalpha) in H4IIEC3 rat hepatoma cells. It decreases plasma glucose and LDL levels and increases plasma levels of HDL in a hamster model of hypercholesterolemia induced by a high-fat diet when administered in the diet at 25 ppm.Formal Name: 4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-phenol. CAS Number: 537-42-8. Synonyms: 3',5'-Dimethoxy Resveratrol, 3',5'-Dimethoxy-4-Stilbenol, trans-3,5-Dimethoxy-4'-Hydroxystilbene. Molecular Formula: C16H16O3. Formula Weight: 256.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS(pH 7.2) (1:5): 0.15 mg/ml. lambdamax: 219, 309, 320 nm. SMILES: COc1cc(/C=C\c2ccc(O)cc2)cc(OC)c1. InChi Code: InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+. InChi Key: VLEUZFDZJKSGMX-ONEGZZNKSA-N. Origin: Synthetic.
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