PSNCBAM-1

PSNCBAM-1 is a cannabinoid 1 (CB1) receptor negative allosteric modulator (NAM). It is selective for CB1 over CB2 in HEK293 cells expressing the human receptors (IC50s = 74.3 and >10,000 nM, respectively). PSNCBAM-1 inhibits activation of the CB1 receptor induced by (±)-CP 55,940 (Cay-13241), anandamide (AEA, Cay-90050), or 2-arachidonoyl glycerol (2-AG, Cay-62160) in yeast expressing human CB1 (IC50s = 45.2, 37 and 230.3 nM, respectively). It reduces food intake within one hour and decreases body weight in male rats when administered at a dose of 30 mg/kg. PSNCBAM-1 (10 mg/kg) reduces THC-induced increases in tail-flick latency in mice.Formal Name: N-(4-chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea. CAS Number: 877202-74-9. Molecular Formula: C22H21ClN4O. Formula Weight: 392.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 229, 260, 342 nm. SMILES: ClC1=CC=C(NC(NC2=CC(C3=NC(N4CCCC4)=CC=C3)=CC=C2)=O)C=C1. InChi Code: InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28). InChi Key: HDAYFSFWIPRJSO-UHFFFAOYSA-N.