PPARgamma Ligand Pack

The Cayman PPARgamma Ligand Pack contains a combination of frequently used ligands for the nuclear PPARgamma. Each kit contains Ciglitazone, the first characterized member of the thiazolidinedione (TZD) class that binds to the PPARgamma ligand-binding domain with an EC50 value of 3.0 µM. Rosiglitazone, a key reference TZD also called BRL 49653, its more potent structural homolog MCC-555, and PPARgamma-1-selective pioglitazone are other PPARgamma agonists provided. Also included is Troglitazone (Resulin(TM)), another TZD, it was withdrawn from human therapeutic use due to hepatotoxicity. Also in this assortment is 15-deoxy-Delta12,14-Prostaglandin J2, a potent PPARgamma ligand derived from PGD2. The actions of all of these compounds can be antagonized by the selective PPARgamma antagonist, GW 9662, which is also in the kit.Synonyms: Peroxisome Proliferator-activated Receptor gamma Pack. Purity: >98%.