Piribedil

Piribedil is a dopamine receptor agonist. It binds to dopamine D2, D3, and D4 receptors (IC50s = 1-1,000 nM in radioligand binding assays). Piribedil (1 and 10 mg/kg) enhances spontaneous object recognition in young adult rats and attenuates age-related memory impairments in the radial arm maze in mice. It reduces immobility time in the forced swim test in mice when administered at doses ranging from 0.63 to 10 mg/kg. Piribedil (0.3 mg/kg) decreases the number of premature and delayed responses in a response time test, indicating improved attentional function, in a rat model of Parkinson's disease induced by 6-OHDA (Cay-25330) when administered in combination with L-DOPA (Cay-13248).Formal Name: 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-pyrimidine. CAS Number: 3605-01-4. Molecular Formula: C16H18N4O2. Formula Weight: 298.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMF:PBS (pH 7.2) (1:6): 0.14mg/mL, DMSO: 5mg/mL, Ethanol: 5mg/mL. lambdamax: 242 nm. SMILES: N1(C2=NC=CC=N2)CCN(CC3=CC(OCO4)=C4C=C3)CC1. InChi Code: InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2. InChi Key: OQDPVLVUJFGPGQ-UHFFFAOYSA-N.